The Insides Company's flagship product, The Insides® System, is a medical device that enables chyme to be reinfused into the intestine for enterostomy and enterocutaneous fistula patients.
The Insides System is commercially available in the United Kingdom, Europe, and New Zealand.
*The Insides System is not available in other markets.
The Insides System has won GOLD at the 2021 MDEAs in the Gastrointestinal and Genitourinary Devices category
Supplying the world’s leading intestinal failure and rehabilitation centres
The Insides Company is founded by world-leading pioneers in gut surgery, and is commercialised by med-tech veterans. The Insides System is now being used in may of the world's leading international intestinal failure centres.
Please contact us today to learn about how The Insides System can impact your Intestinal Failure patient's journey to recovery.
Professor Ian Bissett Co-Founder & Chief Medical Officer
“Encourage the formation of double stomas and the consideration of the use of the distal opening for re-infusion of chyme in the setting of an entero-atmospheric fistula.”
Emma Ludlow Clinical Nurse Specialist Ostomy
"The Insides® System allows me to support, and optimise my patient’s journey to recovery."
For the effective chyme reinfusion treatment of enterocutaneous fistulas and high-output enterostomies
Under the standard care pathway, patients recovering from colorectal surgery often have an enterostomy created to divert intestinal contents (chyme) away from the surgical site as it heals.
The enterostomy is typically left open for 6-12 months, and during this time, the chyme that is collected is disposed which can result in intestinal failure
The Insides System, is a chyme reinfusion solution, which enables diverting enterostomy, and enterocutaneous patients to reinfuse chyme back into their intestine, allowing them to recommence oral feeding and reduce length of stay in hospital.
Key Clinical Benefits of Chyme Reinfusion
Earlier return to oral feeding1
Patients able to recommence oral feeding
Improved nutritional outcome2
Increase in nutritional risk index by 10.9 (± 9.5) with a 85% reduction in intestinal losses
Improved restoration of gut function3
Limiting gut atrophy and inflammation
Improved renal function4-5
Prevents dehydration and reduces the potential for chronic kidney disease
Improved liver function5-6
53% reduction in plasma liver test abnormalities
Wean off Parenteral Nutrition6
>91% of patients weaned off parenteral nutrition within a median of 2 days (± 9)
1. Sharma P, Davidson R, Davidson J, Keane C, Liu C, Ritchie SR, et al. Novel chyme reinfusion device for gastrointestinal fistulas and stomas: feasibility study. Br J Surg [Internet]. 2020 Apr 18; Available from: http://doi.wiley.com/10.1002/bjs.11516 2. Picot D, Layec S, Dussaulx L, Trivin F, Thibault R. Chyme reinfusion in patients with intestinal failure due to temporary double enterostomy: A 15-year prospective cohort in a referral centre. Clin Nutr [Internet]. 2017 Apr;36(2):593–600. Available from: https://linkinghub.elsevier.com/retrieve/pii/ S0261561416300668 3. Pflug AM, Utiyama EM, Fontes B, Faro M, Rasslan S. Continuous reinfusion of succus entericus associated with fistuloclysis in the management of a complex jejunal fistula on the abdominal wall. Int J Surg Case Rep [Internet]. 2013;4(8):716–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/ S221026121300179X 4. Fielding A, Woods R, Moosvi SR, Wharton RQ, Speakman CTM, Kapur S, et al. Renal impairment after ileostomy formation: a frequent event with long‐term consequences. Color Dis [Internet]. 2019 Oct 17;codi.14866. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1 111/codi.14866 5. Dilke, S. M., Gould, L., Yao, M., Souvatzi, M., Stearns, A., Ignjatovic-Wilson, A., Tozer, P., & Vaizey, C. J. (2021). Distal feeding–bowel stimulation to treat short-term or long-term pathology: a systematic review. Frontline Gastroenterology, 12(7), 677–682. https://doi.org/10.1136/flgastro-2019-101359 6. Layec S, Seynhaeve E, Trivin F, Carsin-Mahé M, Dussaulx L, Picot D. Management of entero-atmospheric fistulas by chyme reinfusion: A retrospective study. Clin Nutr [Internet]. 2020 Apr; Available from: https://linkinghub.elsevier.com/retrieve/pii/ S0261561420301485
Contact The Insides Company today to learn more about our revolutionising treatments for intestinal failure patients